Graded global ischemia and reperfusion. Cardiac function and lactate metabolism.
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چکیده
منابع مشابه
Graded global ischemia and reperfusion. Cardiac function and lactate metabolism.
The effect of global ischemia of different degrees of severity and reperfusion was studied in the isolated working rat heart. Four degrees of ischemia were induced by reducing the control total coronary flow of 8 ml/min to 0, 0.04, 0.4, or 0.8 ml/min for 30 minutes, after which the coronary flow was returned to the control level. After severe ischemia (0 and 0.04 ml/min ischemic coronary flow g...
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measured in vivo. Circ Res 22: 199-212, 1968 20. Burton AC: On the physical equilibrium of small blood vessels. Am J Physiol 164: 319-329, 1951 21. Smiesko V: Unidirectional rate sensitivity component in local control of vascular tone. Pfluegers Arch 327: 324-336, 1971 22. Mellander S, Arvidsson S: Possible "dynamic" component in the myogenic vascular response related to pulse pressure distensi...
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Ischemia-reperfusion generates peroxynitrite (ONOO-), which interacts with many of the systems altered by ischemia-reperfusion. This study examines the influence of endogenously produced ONOO- on cardiac metabolism and function. Nitro-L-arginine (an inhibitor of ONOO- biosynthesis) and urate (a scavenger of ONOO-) were utilized to investigate potential pathophysiological roles for ONOO- in a ra...
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Varadarajan, Srinivasan G., Jianzhong An, Enis Novalija, Steven C. Smart, and David F. Stowe. Changes in [Na]i, compartmental [Ca ], and NADH with dysfunction after global ischemia in intact hearts. Am J Physiol Heart Circ Physiol 280: H280–H293, 2001.—We measured the effects of global ischemia and reperfusion on intracellular Na, NADH, cytosolic and mitochondrial (subscript mito) Ca, relaxatio...
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ژورنال
عنوان ژورنال: Circulation
سال: 1977
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.55.6.864